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Melanotan-II treatment resulted in weight loss but did not affect repetitive or anxiety-like behavior of normal C57BL/6J mice MC4R stimulation has been linked to increased stress behaviors based on its effects on the hypothalamic-pituitary-adrenal axis [41]

While not approved specifically for weight loss, clinical trials showed average weight reduction of 3-5% of body weight, making it the least potent option in this category for weight management

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