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In regard to the European Medicines Agency recommendation to update the product information for Novo Nordisk medications Ozempic, Rybelsus, and Wegovy to indicate NAION is a very rare risk, the company told Spotlight: Based on the totality of evidence Novo Nordisk concluded that the data did not suggest a reasonable possibility of a causal relationship between semaglutide and NAION and that the benefit-risk profile of semaglutide remains favorable

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Furthermore, these behavioral outcomes were substantiated by a key neurobiological finding: the significant upregulation of hippocampal BDNF, a critical mediator of neuroplasticity and resilience