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3 Drugs to Treat the Motor Symptoms of PD The modern era of pharmacological treatments for the motor symptoms of PD started with the pioneering discoveries of the antagonizing effects of levodopa on the akinesia induced by reserpine in rabbits by the Swedish pharmacologist Arvid Carlsson [10] and of dopamine depletion in the striatum of brains from PD patients by the Austrian pharmacologist Oleh Hornykiewicz, who together with the neurologist Birkmayer also reported on the striking effects of small doses of intravenous levodopa on PD motor symptoms [11]

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This gentle approach prevents foaming, which creates air-liquid interfaces where peptides denature and aggregate irreversibly