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The palmitoyl chain (C16 palmitic acid) grafted onto each peptide confers increased lipophilicity, facilitating passage through the lipid barrier of the stratum corneum and allowing the peptides to reach the deeper layers of the epidermis and the superficial dermis

Interestingly, the C-terminus of exendin-4 may be required to facilitate formation of high order GLP-1R oligomers through interaction with neighbouring GLP-1R protomers in trans (Koole et al ., 2017)

In the literature, there is evidence about the roles of MDA and 4-HNE in the inflammatory process, which occurs in diseases such as psoriasis and vitiligo

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