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Moreover, damage or weakness in the heart muscle itself, disorders of the valves such as stenosis or regurgitation, endocardium, cardiac conduction and rhythm, pericardium, or all of these changes can cause HF [43, 44]
Nat Rev Mol Cell Biol 8:813824 Brigelius-Flohe R (1999) Tissue-specific functions of individual glutathione peroxidases
This means that during postnatal development in diseased retinas, greater excretion of GSSG, into extracellular space where it get hydrolyzed, could lead to an increase in the [GSH]/[GSSG] ratio
The daily injection routine can be a compliance challenge for some patients
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