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Weakened ligaments can lead to: Joint deformity Contractures (a permanent tightening that causes the joint to shorten and stiffen) Increased pain Rheumatoid arthritis can also cause damage to blood vessels, skin, lungs, eyes, heart, and the nervous system

N Engl J Med 364(6):514523 Pavel ME et al (2017) Health-related quality of life for everolimus versus placebo in patients with advanced, non-functional, well-differentiated gastrointestinal or lung neuroendocrine tumours (RADIANT-4): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

However, as mentioned, the data and methods are unchanged

Reason 4: Cost-benefit mismatch