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Metabolic syndrome is characterised by insulin resistance and consequent hyperinsulinaemia - hyperinsulinaemia is associated with increased appetite and consequent weight gain which then compounds the insulin resistance

For anyone using retatrutide within a clinical trial or authorised protocol, the only in-use shelf life that should be followed is the one stated on the IMP label or in the trial protocol, as validated by the trial sponsor

It is an agonist at the trace amine-associated receptor (TAAR1), stimulating the release of both norepinephrine and epinephrine

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