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For Canadian researchers evaluating their options, the pricing framework should weigh total delivered cost (vial price + shipping + taxes), quality evidence (verifiable Janoshik COA, 99% HPLC, synthetic SPPS manufacturing), and operational factors (transit time, cold-chain handling, payment flexibility) together

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While these values should not be applied directly due to heterogeneity across studies, they highlight the modest, yet clinically meaningful, impact of SGLT2Is on mortality outcomes in HFpEF

Diabetes Care 2017