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Centrilobular (Figures 5459) Sometimes referred to as periacinar necrosis, it consists of irreversible cell death of centrilobular hepatocytes and is often seen after anoxia, or exposure to tannic acid, chloroform, or other hepatotoxic agents (Gopinath, Prentice, and Lewis 1987)

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When comparing the responders from the CRWP group ( n = 12) to the non-responders in the same group ( n = 7), there was a significant difference in age with the responders being significantly older (4.23 0.22 years) than non-responders (3.48 0.18 years

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