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4 Department of Natural and Life Sciences, Long Island University, Brooklyn, NY, 11201, USA Correspondence: Dong H Kwon, Department of Natural and Life Sciences, Long Island University, 1 University Plaza, Brooklyn, NY, 11201, USA, Tel +1 718 780 4098, Fax +1 718 488 1465, Email [email protected] Abstract: Antibiotic resistance has spread globally among bacterial pathogens, becoming a significant challenge to public health

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In HepG2 cells, the expression of CAR and its target genes (CYP2B6 and CYP3A4) is inhibited by berberine, which increases DNA methylation and interferes with CAR binding to gene promoters (118)