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These anti-inflammatory studies established the immunomodulatory biology of MC1R activation as a significant pharmacological property of MT-1 beyond its pigmentary effects

The concern is dosing accuracy, not safety

The method of embodiment 81, wherein the external beam radiation therapy is three-dimensional conformal radiation therapy (3D-CRT), image guided radiation therapy (IGRT), intensity modulated radiation therapy (IMRT), helical-tomotherapy, photon beam radiation therapy, proton beam radiation therapy, stereotactic radiosurgery, stereotactic body radiation therapy (SBRT), or intraoperative radiation therapy (IORT)