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Discontinuation rates (tolerability issues) 12.2% discontinued the 9 mg dose and 18.2% discontinued the 12 mg dose due to adverse events, compared to 4% in the placebo group

One review showed that people lost about 4 lbs of body weight when taking berberine regularly (500 mg daily)

But you should reach out to your prescribing physician if you experience any of the following: Symptoms that are severe or worsening after two weeks at the same dose Signs of dehydration such as dark urine, dizziness, dry mouth, or rapid heart rate Blood in your stool or severe abdominal cramping Inability to keep food or fluids down Fever accompanying your symptoms Your provider can slow your dose escalation schedule, temporarily reduce your dose, or recommend supportive medications

The main adverse events of LIXI are gastrointestinal adverse reactions, mainly manifested as nausea and vomiting in the initial stage (75, 76)