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You can find additional explanations in the later sections of the article that will enhance your understanding

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Heavy drinking, as defined by the Mayo Clinic, is having more than three drinks a day for women and men over 65, and more than four drinks per day, or more than 14 drinks a week for men younger than 65

The overlapping three-dimensional structures of RIFA and human GSTs revealed clear coincidences, as shown in Figure 6