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In particular, they play a role in vascular protection by reducing endothelial cell apoptosis through the p38 inhibition

Endocr Soc, J

This was shown in HEK 293 cells, known to have voltage-gated K + [272,273], Na + [274], and Ca 2+ [275] channels, and with different local anesthetics applications (i.e., bupivacaine [89], lidocaine [60], tetracaine [276], and oxibuprocaine [276])

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