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In addition, there was a clinically relevant improvement in cognitive performance in at least three out of 15 individuals

Discussion High Pyroglutamic acid indicates a disturbed GSH homeostasis in symptomatic TTR-V30M gene carriers In a recent study, we demonstrated that the formation of the aggregation-prone NNTTR species, initially discovered in plasma from TTR-V30M gene carriers [21], is promoted by the formation of a disulfide bridge [22]