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Study designs to investigate causality rigorously Prospective new-user cohort with active comparator + Recruit new semaglutide users and matched new users of a comparator second-line diabetes therapy with lower genital infection confounding (e.g., DPP4 inhibitor), stratified by menopausal status and baseline GSM

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If a product has not been FDA-approved to treat a condition, it cannot be promoted as safe and effective for treating that condition

A substantial body of evidence suggests that both peripheral innate immune cells (such as neutrophils, macrophages, and natural killer cells) and adaptive immune cells (like T cells and B cells) are present in the cellular infiltration of the cerebral embolism area