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doi: 10.1016/j.cell.2012.03.042 83 YangWSStockwellBR

& Kolesar, J

The central clinical idea: when mitochondrial ATP production falls and oxidative stress rises, the brain may lose the energy and antioxidant reserve needed to regulate neurotransmission, maintain cell membranes, recycle methionine, produce SAM, clear adenosine and homocysteine, build glutathione and tolerate medications or supplements