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The oxidation of glucose-6-phosphate (G6P) in the PPP generates NADPH, a reducing equivalent that sustains glutathione (GSH) in its reduced state and protects the cell from oxidative injury (Nemkov et al., 2018)

It is also possible that HPA sensitivity rather than HPA axis dysfunction exists in patients (63)

These tumors are distinguished from their benign counterpart by the presence of severe nuclear atypia, hypercellularity, and high mitotic activity

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