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Specifically, GLP-1Rs on vagal afferent neurons have been shown to contribute to the incretin effects of GLP-1 shortly after a meal, gastric emptying, and glycemia (Krieger et al., 2015)

The GCGR component is particularly important for researchers studying energy expenditure rather than just appetite suppression

Subsequently, HIF-1 influences the expression of numerous genes that are crucial for gastric carcinogenesis