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Visual inspection catches only the most advanced stages of degradation

Critical limitations identified in the systematic review include predominant use of small rodent models (primarily rats), short follow-up periods relative to human healing timelines, variable dosing regimens complicating dose-response assessment, and lack of standardized outcome measures across studies

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however, higher ACSL4 expression corresponds to a lower IC50 value of sorafenib in RCC patients, indicating that these ferroptosis-related genes are closely related to drug sensitivity (Fig