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Consistent with the mean of 10% weight loss observed in the naltrexone-bupropion group, which was maintained through 12 months, we observed modest improvements in the obesity-related parameters in several domains relevant to cardiometabolic risks: glycaemic control (HbA1c), lipid metabolism (LDL-C levels), liver parameters (ALT and AST levels, CAP and LS on VCTE)
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It has comparable GIP receptor binding affinity to native GIP but five-times lower GLP-1R affinity than native GLP-1 and is thus an imbalanced co-agonist
During treatment: In clinical trials, people reached target doses ranging from 0.5mg to 12mg weekly, depending on their assigned group
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