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Table of Contents The continued rise and prevalence of diabesity, obesity, and related metabolic disorders, has driven consumers to explore a variety of dietary approaches and even pharmacological interventions for effective weight management

The rats were randomly divided into seven groups using a simple randomization method: the Sham group, middle cerebral artery occlusion (MCAO) group, MCAO + ST 200 mg/kg group, MCAO + ST 400 mg/kg group, and MCAO + ST 600 mg/kg group

Although these therapies offer distinct mechanisms, their clinical translation remains limited by safety concerns, poor translatability, and inadequate weight-loss efficacy as monotherapies