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Tirzepatide binds the GLP-1 receptor with lower affinity than semaglutide and exhibits distinct signaling bias, which may result in comparatively different downstream GLP-1 receptor signaling dynamics 23

Instead, the term "enlargement" was peculiarly defined by the lead investigators as "echocardiographic and radiographic evidence of cardiac enlargement by 3 different heart size criteria." Note that the EPIC Study investigators ignored ACVIM's term, " findings of left-sided heart enlargement ", and substituted "heart size criteria"

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Stress & Poor Sleep : These weaken immune regulation and increase inflammation