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Pancreatic acinar cell-specific autophagy disruption reduces coxsackievirus replication and pathogenesis in vivo

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Sandoval and Klaus Weber reported in 1978 that large microtubule-associated proteins MAP1 and MAP2 (that are crucial for tubulin assembly) are rapidly degraded in crude brain extracts by a calcium-dependent protease, which does not affect tubulin, and this event results in the permanent loss of tubulin polymerization (Sandoval and Weber, 1978)

However, its potential delayed toxicity related to cobalt accumulation in tissue remains unknown