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Coupling of folding and binding for unstructured proteins

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The most common genetic alterations in GBM involve the inactivation of tumor suppressor genes, such as p53, PTEN, and retinoblastoma (RB1), leading to uncontrolled cell proliferation, escape from apoptosis, and genomic instability [14, 16]

Mice with deletion of Gipr in neurons of the PNS were generated by crossing C57BL/6J Gipr flx/flx mice 35,36 with C57BL/6J mice that express Cre -recombinase under control of the promoter for peripherin (MGI 3841120) 37