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Gastrointestinal AE with cagrisema were more than with semagutide or cagrilintide monotherapy, however the SAE and AE leading to medication discontinuation were minimal and similar between the groups [87, 90] A programme of phase 3 clinical trials (REDEFINE) assessing the safety and efficacy of cagrisema in people with obesity (NCT05567796, NCT05394519, NCT05813925) is currently ongoing

User reports commonly describe improvements in bloating, digestive discomfort, and bowel regularity within 1 to 2 weeks, with full therapeutic benefit emerging over 4 to 6 weeks

This regimen should be followed by 100 mcg monthly for life

Can B12 injections be self-administered, and what are the safety protocols