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Furthermore, in rats that are subjected to cecum ligation and puncture (CLP) induced-AKI, early glomerular syndecan-1 loss is followed by the loss of hyaluronic acid 7 h after CLP is initiated, and this is accompanied by alterations in glomerular sialic acids and the molecular composition of the glomerular filtration barrier (95)

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While long-term PCOS-specific trials continue, current evidence supports GLP-1 therapy as a physiologically sound intervention for insulin-resistant PCOS management