GIP (Metabolic Efficiency) Like Zepbound, Retatrutide activates the Glucose-Dependent Insulinotropic Polypeptide (GIP) receptor
Farkas I, Vastagh C, Farkas E, Balint F, Skrapits K, Hrabovszky E et al (2016) Glucagon-Like Peptide-1 Excites Firing and Increases GABAergic Miniature Postsynaptic Currents (mPSCs) in Gonadotropin-Releasing Hormone (GnRH) Neurons of the Male Mice via Activation of Nitric Oxide (NO) and Suppression of Endocannabinoid Signaling Pathways
If this math feels uncomfortable, you are not alone
In severe cases, lesions may even be observed in the thalamus, basal ganglia, midbrain, hippocampus, and cerebral cortex (McMillan et al., 2023).The pathologic hallmarks of JEV-infected patients are neuron loss and microglia activation (Liao et al., 1998)