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N-3 PUFAs enhance VDR expression by attenuating neuroinflammation 105,110,111 , and activating the Nrf2 pathway, which mitigates oxidative stress-linked VDR suppression 112,113,114

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Not surprisingly, a subset of DPP-4 inhibitors evaluated during pre-clinical development were found to suppress DPP-8 and/or DPP-9 activity, causing severe toxicities, including weakened T cell activation and proliferation, impaired preadipocyte differentiation (Han et al., 2015), enlarged lymph nodes, splenomegaly, etc