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Transcriptomics and biochemical evidence of trigonelline ameliorating learning and memory decline in the senescence-accelerated mouse prone 8 (SAMP8) model by suppressing proinflammatory cytokines and elevating neurotransmitter release

Multiple studies across both animal models and human populations have shown that different durations, intensities, and types of exercise can enhance BDNF levels and activate downstream signaling pathways critical for brain health (23, 24)

Moreover, HPL restored alanyl-aminopeptidase (Anpep) expression and metabolite shifts, promoting antioxidative metabolite processing, and recovery

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