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The cut-off point ranges from 3 to 5.1 g/L when hypoglycemia is 30 kg/m2) and over-weight (BMI 25 to 30 kg/m2) patients with a low pretest probability, we recommend a lower cutoff of 1 g/L to avoid false-positive diagnosis, because obesity physiologically reduces GH responses to stimulation tests (44)

Thats the big research and policy question and Jen Manne-Goehler and team do a great job outlining the various studies we need to see if some can off-ramp after achieving weight loss

The slower, more controlled release from subcutaneous tissue is by design

Track mean plasma IGF1 to gauge response and safety since IGF1 elevation links to both benefits and theoretical cancer risks