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Although a large number of short-term and medium-term clinical studies support the safety and efficacy of GLP-1RAs, there are insufficient data on the presence of delayed side effects with their long-term (decades) use (Guirguis et al., 2024)

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10.1016/j.bmcl.2014.03.021 Bioorg Med Chem Lett

In other embodiments, when an even more viscous medium is desired, the biocompatible gel comprises at least about 35%, at least about 45%, at least about 55%, at least about 65%, at least about 70%, at least about 75%, or even at least about 80% or so by weight of the active agent