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These interactions occur at various stages, from ingestion to the final reabsorption in the excretion system

As a consequence, IEC metabolism shifts to anaerobic pathways leading to elevated mucosal oxygen concentrations, thereby facilitating colonisation by facultative anaerobes which are responsible for gut-associated inflammation (Byndloss et al

Next, we introduced multiple mutations in HGF, including point mutations (W321R, E336R, E361R, R373E, and Y376A), double mutation (W321R/Y376A), and triple mutation (W321R/E361R/Y376A), designed to weaken the interface III

This fibrotic process contributes significantly to the clinical burden of the disease, particularly chronic pain and infertility [26]