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Vitamin C and Copper Research suggests that taking vitamin C and copper together may promote free radical formation, which could contribute to oxidative stress and potential kidney damage in high doses or prolonged use
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A logical target whereby metformin could mediate its putative antiproliferative effects in cancer is via inhibition of mTOR and the serine-threonine kinase, ribosomal S6K (pS6K), either via activation of AMPK or via an AMPK-independent pathway (241, 242)
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