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Alcohol is mainly metabolized in the body through the liver

Aizawa K, Iemitsu M, Maeda S (2010) Acute exercise activates local bioactive androgen metabolism in skeletal muscle

These can be specific or broad-spectrum pumps

The abnormal activation of innate immune cells, as summarized in Figure 1, involves multi-dimensional mechanisms such as metabolic reprogramming, inflammasomes, complement pathways, and intercellular signal crosstalk, providing a rich theoretical basis for the development of immune-targeted therapeutic strategies for PH