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Long-term safety questions remain under study

In the STEP trials, participants taking semaglutide 2.4 mg weekly lost an average of 15% of their body weight over 68 weeks, compared to 2.4% in the placebo group

( B O ) Flow cytometry analysis of CD45 + cells ( B ), neutrophils ( C ), Ly6G hi monocytes ( D ), total macrophages ( E ), CD206 + CD301b + M2 macrophages ( F ), Arg + M2 macrophages ( G ), iNOS + M1 macrophages ( H ), CD45 + CD4 + T cells ( I ), Gata3 Th2 cells ( J ), Rort Th17 cells ( K ), T-bet Th1 cells ( L ), Foxp3 + Tregs ( M ), IL-17 + Tregs ( N ), and Rort + Foxp3 + Tregs ( O ) in eWAT of 18- to 22-week-old male WT and Bbs5 / mice ( n = 46 per group)

Many patient complaints stem not from poor service but from mismatched expectations