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Baseline WOMAC pain score: approximately 6 out of 20 Reduction in active treatment arms: approximately 4.5 points , representing a ~76% decrease from baseline Complete freedom from knee pain at week 68: reported by roughly 1 in 8 patients (12.5%) receiving retatrutide, compared to just 4.2% in the placebo group A 76% reduction in pain scores is extraordinary approaching the range typically seen after total knee replacement surgery

When appropriate, supplements can support your hormones and metabolism, giving your body what it needs to function and feel well during these pivotal years

However, you may not see clinical effects like pronounced weight loss or changes in your A1C until around 12 weeks, since HbA1c tests measure your average glucose level based on the previous three months

And some patients, especially those who are elderly with already low muscle mass, might need extra help preserving their strength