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The WD40 co-crystal structures with the wild-type and clientized Thr127Glu S heptapeptides were determined to a resolution of 1.4 (Supplementary Table S3)

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Whereas GIP exerts positive effects on pancreatic -cell proliferation and survival similar to that shown for GLP-1, the hormone does not affect glucagon secretion nor gastric emptying

Current research into the function of PregS is impeded by the lack of selective/specific antagonists and by a lack of knowledge of validated binding site(s)