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Injection of fluorescent liraglutide labelled neurons in circumventricular organs, as well as the arcuate nucleus, showed brain uptake of labelled liraglutide was abolished in Glp1r / mice, showing that brain uptake of liraglutide is dependent on the canonical GLP-1R (11)

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In the study, participants who received supervised exercise instruction maintained a weight loss of at least 10% of initial body weight one year after treatment termination compared with those who received liraglutide alone or placebo (4)