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[18] [5] Rapid weight loss associated with this class of medication may increase the risk of gallbladder disease, including gallstones

These disorders can be associated with insulin resistance, hyperglycemia-induced damage, oxidative stress, astrocyte abnormalities, and mitochondrial dysfunction, resulting in insufficient energy supply, altered synaptic plasticity, death of neuronal cells, as well as functional and structural damage to reward networks

of duplicate (binding assay) or quadruplicate (cAMP assay) measurements

Notably, a marginal increase in risk (RR 1.34, 95% CI 1.04, 1.72) was observed in studies with methodological flaws 41