Centralized pain processing Women with IC/BPS frequently have other concurrent functional pain syndromes, including fibromyalgia, irritable bowel syndrome, and vulvodynia
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Crocin, crocetin, picrocrocin, and safranal are the principal active compounds in saffron which exhibit a wide spectrum of biological activities including analgesia, antioxidant activity, cardiovascular protection, and inhibition of cancer, diabetes, inflammation, and depression, among others [518, 519]