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Two 2013 systematic reviews of interventions concluded that the modest benefit of propionyl-L-carnitine on walking performance was equivalent or superior to that obtained with drugs approved for claudication in the US (e.g., pentoxyphylline, cilostazol) yet inferior to improvements seen with supervised exercise interventions (69, 70)

The 13 amino acid N-terminal extension and arginine substitution at position 3 reduce IGFBP binding by about 100-fold while keeping high affinity for the IGF-1 receptor

doi: 10.3389/fmicb.2016.01457, 4 AllemannM

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