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Unlike the application in relatively closed joint cavities and fluid environments, the intestinal environment features acid-base gradients, digestive enzymes, food flow, and complex flora, making it extremely easy for drugs to be diluted or inactivated

10.1016/0005-2744(80)90004-2 37 LahtiP

Silencing of miR122 has been shown to upregulate CAT-1 ( SLC7A1 ) expression, and subsequently increase arginine uptake to maintain large intracellular arginine pools for nitric oxide (NO) synthesis, resulting in increased resistance to the multi-kinase inhibitor sorafenib (Kishikawa et al., 2015)