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This ingredient naturally occurs as piceol in Norwegian spruce needles (~0.4-1.1% dry weight and in cloudberries)

It seems, however, that while stimulation of some GLP-1R expressing neuronal populations is responsible for reducing food intake in association with nausea or aversion stimulation of others can lead to food intake reduction via mechanisms independent of nausea (McMahon and Wellman, 1998

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Intraperitoneal glucose tolerance tests (IPGTTs) C57BL/6 WT mice were fed a standard chow diet or a rodent diet with 10 kcal% fat and 2% cholesterol (D01101902CR, Research Diets, Inc) for 5 weeks (8-9 female mice per condition)