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IV zinc may be considered when oral intake is not tolerated, absorption is impaired, or short-term repletion is clinically indicated.

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Binding of -MSH to MC4R triggers a Gs protein-coupled signaling cascade, which increases intracellular cyclic AMP (cAMP) levels and ultimately activates downstream pathways that promote satiety and increase energy expenditure [9]

The full prescribing information is available via the electronic medicines compendium