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In 2004, the Department of Health and Human Services recognized obesity as an illness, and in 2013, the American Medical Association did as well

This genetic context may help provide insight into why certain individuals experience more pronounced nausea, faster weight loss, or different side effect patterns compared to others on the same dose

Upregulated PYCR1 expression has been demonstrated to activate STAT3 phosphorylation in lung cancer, which in turn leads to elevated PD-L1 expression and subsequent inhibition of T cell infiltration [113]