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That constraint is why dose-finding trials matter so much for this class: the dose is the only lever left once the receptor ratio is baked in

Second, the study identified another genetic variant that is associated with side-effects, specifically nausea and vomiting, while using tirzepatide (Mounjaro or Zepbound)

Anna Secher, a scientific director within Obesity and MASH (metabolic dysfunction-associated steatohepatitis) at Novo Nordisk, discussed what is known about how GLP-1R agonists gain access into the brain