So far, six patients with clEDS and tissue fragility have been reported in the literature, predominantly but not exclusively of the gastrointestinal tract: (1) perforation of colonic diverticulum, development of multiple abscesses requiring partial colectomy, complicated by second small bowel perforation in a 36-year-old man
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It is crucial to understand that the liver itself does not have pain receptors, so pain is typically referred from surrounding structures or due to inflammation, swelling, or other pathological changes