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They were initially defined as secretory GPX, but later studies have shown that both enzymes are localized to the endoplasmic reticulum and are necessary enzymes involved in the oxidative folding of endoplasmic reticulum proteins (Figure 8)

When this happens, the digestive tract has a large opening which causes the stomach to be filled with gastric fluids, and this can lead to a dangerous infection

Increased transcription of the regulatory subunit of -glutamylcysteine synthetase in rat lung epithelial L2 cells exposed to oxidative stress or glutathione depletion

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