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Perhaps that chronic dehydration leads to increased risk of stones. The drugs also appeared to be linked to kidney benefits, too

Common side effects of GLP-1 may include nausea and constipation, with 0.3% of participants reporting unmanageable side effects

Those in the trial that did experience negative side effects did so at the same rate and consistency as those previously reported for injectable GLP-1 drugs and Eli Lilly said it "was consistent." The drugmaker said the most commonly reported negative side effects were mild to moderate gastrointestinal-related symptoms, such as nausea, constipation, indigestion, diarrhea and vomiting

However, it is not a replacement for insulin, particularly in type 1 diabetes, as it does not perform the vital functions of insulin in glucose metabolism